Hyperimmune globulin is similar to intravenous immunoglobulin (IVIG) except that it is prepared from the plasma of donors with high titers of antibody against a specific organism or antigen. Some agents against which hyperimmune globulins are available include hepatitis B, rabies, tetanus toxin, varicella-zoster, etc. Administration of hyperimmune globulin provides "passive" immunity to the patient against an agent. This is in contrast to vaccines that provide "active" immunity. However, vaccines take much longer to achieve that purpose while hyperimmune globulin provides instant "passive" short-lived immunity. Hyperimmune globulin may have serious side effects, thus usage is taken very seriously.
Treatment with hyperimmune globulin in mothers with primary cytomegalovirus (CMV) infection has not been found to significantly decrease the risk of congenital cytomegalovirus infection.
Hyperimmune serum
Hyperimmune serum is blood plasma containing high amounts of an antibody. It has been hypothesised that hyperimmune serum may be an effective therapy for persons infected with the Ebola virus.