Hydroxyphenylpyruvate reductase

In enzymology, a hydroxyphenylpyruvate reductase (EC 1.1.1.237) is an enzyme that catalyzes the chemical reaction

Thus, the two substrates of this enzyme are 3-(4-hydroxyphenyl)lactate and NAD⁺, whereas its 3 products are 3-(4-hydroxyphenyl)pyruvate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is 4-hydroxyphenyllactate:NAD⁺ oxidoreductase. This enzyme is also called HPRP. This enzyme participates in tyrosine metabolism and phenylalanine metabolism.