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Hydroxymethylglutaryl CoA reductase (NADPH)

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EC number
  
1.1.1.34

IntEnz
  
IntEnz view

ExPASy
  
NiceZyme view

CAS number
  
9028-35-7

BRENDA
  
BRENDA entry

KEGG
  
KEGG entry

Hydroxymethylglutaryl-CoA reductase (NADPH)

In enzymology, a hydroxymethylglutaryl-CoA reductase (NADPH) (EC 1.1.1.34) is an enzyme that catalyzes the chemical reaction

Contents

(R)-mevalonate + CoA + 2 NADP+ ⇌ (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+

The 3 substrates of this enzyme are (R)-mevalonate, CoA, and NADP+, whereas its 3 products are (S)-3-hydroxy-3-methylglutaryl-CoA, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, to be specific those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. This enzyme participates in biosynthesis of steroids including cholesterol. The statin class of anticholesterol drugs act through inhibiting this enzyme.

Nomenclature

The systematic name of this enzyme class is (R)-mevalonate:NADP+ oxidoreductase (CoA-acylating). Other names in common use include:

  • hydroxymethylglutaryl coenzyme A reductase (reduced nicotinamide
  • adenine dinucleotide phosphate), 3-hydroxy-3-methylglutaryl-CoA reductase
  • β-hydroxy-β-methylglutaryl coenzyme A reductase
  • hydroxymethylglutaryl CoA reductase (NADPH)
  • S-3-hydroxy-3-methylglutaryl-CoA reductase
  • NADPH-hydroxymethylglutaryl-CoA reductase
  • HMGCoA reductase-mevalonate:NADP-oxidoreductase (acetylating-CoA)
  • 3-hydroxy-3-methylglutaryl CoA reductase (NADPH)
  • hydroxymethylglutaryl-CoA reductase (NADPH2).

    • Structural studies

    As of late 2007, 12 structures have been solved for this class of enzymes, with PDB accession codes 1DQ8, 1DQ9, 1DQA, 1HW8, 1HW9, 1HWI, 1HWJ, 1HWK, 1HWL, 2Q1L, 2Q6B, and 2Q6C.

    References

    Hydroxymethylglutaryl-CoA reductase (NADPH) Wikipedia
    (Text) CC BY-SA