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Hydrogen dehydrogenase (NADP )

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EC number
  
1.12.1.3

IntEnz
  
IntEnz view

ExPASy
  
NiceZyme view

CAS number
  
9027-05-8

BRENDA
  
BRENDA entry

KEGG
  
KEGG entry

In enzymology, a hydrogen dehydrogenase (NADP+) (EC 1.12.1.3) is an enzyme that catalyzes the chemical reaction

H2 + NADP+ H+ + NADPH

Thus, the two substrates of this enzyme are H2 and NADP+, whereas its two products are H+ and NADPH.

This enzyme belongs to the family of oxidoreductases, specifically those acting on hydrogen as donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is hydrogen:NADP+ oxidoreductase. Other names in common use include NADP+-linked hydrogenase, NADP+-reducing hydrogenase, hydrogen dehydrogenase (NADP+), and simply hydrogenase (which is ambiguous).

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2AUV.

References

Hydrogen dehydrogenase (NADP+) Wikipedia