Humphrys is a surname. Notable people with the surname include:
Bob Humphrys (1952–2008), BBC Wales sports broadcaster
Fletcher Humphrys (born 1976), Australian actor
Sir Francis Humphrys (1879–1971), British colonial administrator and diplomat
Gary Humphrys (born 1951), Australian businessman and company director
John Humphrys (born 1943), BBC broadcaster
William Humphrys (1794–1865), engraver