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House de la Cerda is a noble line of the Crown of Castile descending from the Infante Ferdinand de la Cerda, eldest son of King Alfonso X. It was one of four noble lineages that arose directly from the Castilian royal family during the thirteenth century and is the origin of the Dukes of Medinaceli.
The origin of the lineage stems from Infante Alfonso de la Cerda (1270–1333), son of the heir to the throne, Infante Ferdinand de la Cerda who died before his father, Alfonso X. The Alfonso X always stated his successor was his grandson Alfonso de la Cerda, instead of his second son, Infante Sancho. This motivated Sancho to revolt against his father. After a long civil war Sancho was finally crowned. Following an unsuccessful invasion by Aragon and Portugal, a peace settlement removed the Infante de la Cerdas from contention for the Castilian throne.
The lineage of La Cerda continued throughout the Middle Ages and was constituted as a noble house of the first rank, playing a leading role in Castilian politics. This line, like others from the Civil War of mid-fourteenth century, continued through the female line to shift the family heirloom until Dona Isabel de la Cerda, married Bernardo de Bearne, first Count of Medinaceli.