Houghton is a surname. Notable people with the surname include:
Adam Houghton (1310-1389), Bishop of St. David's, Lord Chancellor of England
Amo Houghton (born 1926), New York politician
Amory Houghton (1899–1981), American diplomat and scouting notable
Arthur Boyd Houghton (1836–1875), British painter and illustrator
Bob Houghton (born 1947), English football manager
Buck Houghton (1915–1999), American television producer
Chantelle Houghton (born 1983), participant in Celebrity Big Brother
Charles Frederick Houghton (1839–1898), Canadian politician
Claude Houghton (1886–1961), British novelist
Daniel Houghton (1740–1791), Irish explorer of Africa
Don Houghton (1930–1991), British television screenwriter
Douglas Houghton, Baron Houghton of Sowerby (1898–1996), British Labour politician
Douglass Houghton (1809–1845), American geologist
Eric Houghton (1910–1996), English football player and manager
Fred Houghton (–1918), English semi-professional footballer
Harold Houghton (1906–1986), English footballer
Harry Houghton (1906-?), British naval officer who spied for the Polish and Soviet secret services
Israel Houghton (born 1971), American Christian music singer
James Houghton (born 1948), American actor and writer
James R. Houghton, American businessman
John Houghton (martyr) (died 1535), English Catholic priest and martyr
John T. Houghton (born 1931), British scientist
John Houghton (politician), Isle of Man politician
John Houghton (footballer), New Zealand international football (soccer) player
Katharine Houghton (born 1945), American actress
Kris Houghton, known as Kris Kardashian or Kris Jenner, reality TV star
Laura Mersini-Houghton (born 1969), Albanian theoretical physicist-cosmologist
Nick Houghton (born 1954), British Army officer
Peter Houghton (1938–2007), artificial heart transplant patient
Peter Houghton (footballer) (born 1954), English footballer
Ray Houghton (born 1962), Scottish-born Irish footballer
Richard Monckton Milnes, 1st Baron Houghton (1809–1885), English poet and politician
Sherman Otis Houghton (1828–1914), American politician
Stanley Houghton (1881–1913), English playwright
Steph Houghton (born 1988), English footballer
Thomas Houghton (priest) (1859–1951), Irish-born Anglican clergyman
Thomas Houghton (rugby league), English rugby league player
Thomas Houghton (architect) (1840–1903), American architect
Vasey Houghton (1921–2001), Australian politician