Hornsby is a surname. Notable people with the surname include:
Aubrey Hornsby (1895–1981), American U.S. Army officer and aviation pioneerBrian Hornsby (born 1954), English footballerBruce Hornsby (born 1954), American pianist and musicianDan Hornsby (1900–1951), American bluegrass musicianErnest C. Hornsby (born 1936), Chief Justice of the Supreme Court of AlabamaJ. William Hornsby (1927–2007), mayor of Newport News, VirginiaJennifer Hornsby (born 1951), British philosopherKeith Hornsby (born 1991), American basketball player; son of BruceNikki Hornsby, American singer-songwriter, musicianRogers Hornsby (1896–1963), American major league baseball playerThomas Hornsby (1733—1810), British astronomer and mathematician