Hornsby is a surname. Notable people with the surname include:
Aubrey Hornsby (1895–1981), American U.S. Army officer and aviation pioneer
Brian Hornsby (born 1954), English footballer
Bruce Hornsby (born 1954), American pianist and musician
Dan Hornsby (1900–1951), American bluegrass musician
Ernest C. Hornsby (born 1936), Chief Justice of the Supreme Court of Alabama
J. William Hornsby (1927–2007), mayor of Newport News, Virginia
Jennifer Hornsby (born 1951), British philosopher
Keith Hornsby (born 1991), American basketball player; son of Bruce
Nikki Hornsby, American singer-songwriter, musician
Rogers Hornsby (1896–1963), American major league baseball player
Thomas Hornsby (1733—1810), British astronomer and mathematician
