Horne is a surname. Notable people with the surname include:
Alistair Horne (born 1925), British historian
Barry Horne (1952–2001), British animal-rights activist
Barry Horne (footballer) (born 1962), Welsh footballer
Charles Silvester Horne (1865–1914), British minister and politician
Des Horne (born 1939), South African and English footballer
Donald Horne (1921–2005), Australian writer and social critic
Edmond Henry Horne (1864–1953), Canadian prospector
Edward Horne (1835–1908), English clergyman and cricketer
Frederick J. Horne (1880–1959), a four-star admiral in the United States Navy
Henry Horne, 1st Baron Horne (1861–1929), British general
James A. Horne, British sleep scientist and co-developer of the Morningness–eveningness questionnaire
James H. Horne (1874–1959), American college sports coach
James W. Horne (1881–1942), American actor, screenwriter, and film director
James Welton Horne (1853–1922), Canadian land developer, businessman, and political figure
Jim Horne (model) (1917–2008), American model
John Horne (1848–1928), British geologist
John Horne (botanist) (1835–1905), British botanist
Keith Horne (born 1971), South African golfer
Kenneth Horne (1907–1969), English comedian and businessman
Kenneth Horne (writer) (1900–1975), English writer and playwright
Lena Horne (1917–2010), American singer, actress and civil rights activist
Marilyn Horne (born 1934), American opera singer
Mathew Horne (born 1978), British actor and comedian
Matt Horne (born 1970), New Zealand cricketer
Richard Henry Horne (1803–1884), English poet
Thomas Horne (disambiguation), various people
Willie Horne (1922–2001), British rugby league player