Hopley is an English surname. Notable people with the surname include:
Damian Hopley (born 1970), English former rugby union playerEdward Hopley (1816–1869), English painterHannes Hopley (born 1981), South African discus throwerFrederick John Vanderbyl Hopley, (1883-1951), South African sportsmanLizzie Hopley (also known as Elizabeth Hopley), British actress and writerMark Hopley (born 1984), English rugby union playerThomas Hopley, a principal in the Eastbourne manslaughter, an 1860 legal case in England