Hooft or 't Hooft is a Dutch surname. Notable people with the surname include:
Cornelis Hooft (1547–1627), Dutch statesman
Pieter Corneliszoon Hooft (1581–1647), Dutch historian, poet and playwright
Catharina Hooft (1618–1691), woman of the Dutch Golden Age
Willem Visser 't Hooft (1900–1985), Dutch theologian and the first secretary general of the World Council of Churches
Haas Visser 't Hooft (1905–1977), Dutch field hockey player
Francis van 't Hooft (born 1940), Dutch field hockey player
Gerard 't Hooft (born 1946), Dutch theoretical physicist
9491 Thooft (without an apostrophe) is an asteroid named after Gerard 't Hooft
Jotie T'Hooft (1956–1977), Flemish Belgian neo-romantic poet