Holzapfel is a surname. Notable people with the surname include:
Beate Holzapfel (born 1966), retired West German high jumperBrigitte Holzapfel (born 1958), retired West German high jumperHelmut Holzapfel (born 1944), former Hessian Minister of Culture, Chairman of the Hessian Council on LiteratureJames W. Holzapfel (born 1944), American Republican Party politician, served in the New Jersey General AssemblyRichard N. Holzapfel (born 1954), American professor of Church History and Doctrine at Brigham Young University (BYU)Riley Holzapfel (born 1988), Canadian professional ice hockey playerRudi Holzapfel (1938–2005), Irish poet and teacherRudolf Maria Holzapfel (1874–1930), Poland-born Austrian psychologist, philosopher