Holyoake is a surname. Notable people with the surname include:
Francis Holyoake (1567–1653), British lexicographerGeorge Holyoake (1817–1906), English secularist and co-operatorHenry Holyoake (1657–1731), headmaster of Rugby SchoolHolly Holyoake, Welsh classical music singerSir Keith Jacka Holyoake (1904–1983), New Zealand politicianRonald Holyoake (1894–1966), English cricketerThomas Holyoake (1616?–1675), Church of England cleric