Holtzendorff or von Holtzendorff can refer to:
Holtzendorff (noble family) (German: (pl.) die Herren von Holtzendorff), a Brandenburgian (Old Märkisch) noble family, an Uradel der Uckermark, later Silesia, Ostpreußen, Pommerania, Royal Saxony, and Mecklenburg.
Georg Holtzendorff, 19th-century German painter
Henning von Holtzendorff (1853–1919), a German admiral
Joachim Wilhelm Franz Philipp von Holtzendorff (1829–1889), a German jurist
