Holtzclaw is a surname. Notable people with the surname include:
Bill Holtzclaw (born 1964), American politician
Daniel Holtzclaw (born 1986), American former police officer and convicted serial rapist
Henry J. Holtzclaw (1897–1969), United States Department of the Treasury official
James Holtzclaw, American politician
James T. Holtzclaw (1833–1893), American lawyer, railroad commissioner, and Confederate States Army general