Holton is a surname. Notable people with the surname include:
Brian Holton, professional baseball playerCliff Holton, English footballerDeShaun Holton, musician/rapperDavid Holton, professor of Modern GreekEdward D. Holton, American politician and businessmanGary Holton, actor and musicianGerald Holton, professor of physicsHenry Dwight Holton, American physician and Vermont legislatorHart Benton Holton, politicianJim Holton, football playerA. Linwood Holton Jr., Governor of VirginiaAbner Linwood Holton, III, professor of HistoryLuther Hamilton Holton, politician and businessmanMark Holton, actorPat Holton, football playerRobert A. Holton, chemist