Holton is a surname. Notable people with the surname include:
Brian Holton, professional baseball player
Cliff Holton, English footballer
DeShaun Holton, musician/rapper
David Holton, professor of Modern Greek
Edward D. Holton, American politician and businessman
Gary Holton, actor and musician
Gerald Holton, professor of physics
Henry Dwight Holton, American physician and Vermont legislator
Hart Benton Holton, politician
Jim Holton, football player
A. Linwood Holton Jr., Governor of Virginia
Abner Linwood Holton, III, professor of History
Luther Hamilton Holton, politician and businessman
Mark Holton, actor
Pat Holton, football player
Robert A. Holton, chemist
