Holohan is a surname. Notable people with the surname include:
Frank Holohan (born 1957), Irish hurler
John Holohan (hurler) (1891–1947), Irish hurler
Lenny Holohan (born 1985), Irish camogie player
Owen Holohan, Irish hurler
Patrick Holohan (born 1988), Irish mixed martial artist
Pete Holohan (born 1959), American football player
Richard Holohan (1882–1954), Irish politician