Holmes is the given name of:
Holmes Beckwith (1884–1921), American political scientist and professor who killed his dean and then himselfHolmes Colbert, Native American leader of the Chickasaw Nation and writer of the Chickasaw Nation's constitution in the 1850sHolmes Conrad (1840–1915), American politician, lawyer and military officerHolmes Herbert (1882–1956), English character actorHolmes Osborne (born 1947), American actorHolmes Rolston III (born 1932), philosopher, author and professorHolmes Tuttle (1906–1989), American businessman and political adviser to Ronald Reagan