Holmes is the given name of:
Holmes Beckwith (1884–1921), American political scientist and professor who killed his dean and then himself
Holmes Colbert, Native American leader of the Chickasaw Nation and writer of the Chickasaw Nation's constitution in the 1850s
Holmes Conrad (1840–1915), American politician, lawyer and military officer
Holmes Herbert (1882–1956), English character actor
Holmes Osborne (born 1947), American actor
Holmes Rolston III (born 1932), philosopher, author and professor
Holmes Tuttle (1906–1989), American businessman and political adviser to Ronald Reagan
