Holbein is a surname of Germanic origin. It appears to mean "hollow leg" (Hol- + Bein); however, it could also have originally meant "hollow bone" or perhaps even have evolved from Holzbein, which could mean "wooden leg" or "wooden bone".
Some notable people with the surname include:
Hans Holbein the Elder (1460–1524), German painterHans Holbein the Younger (c. 1497–1543), son of Hans Holbein the Elder, court artist to King Henry VIII of EnglandAmbrosius Holbein (1494–1519), German painter, son of Hans Holbein the ElderSigmund Holbein (died 1540), German painter, brother of Hans Holbein the ElderMontague Holbein, British cyclist, runner-up of the first Bordeaux–Paris cycle race in 1891