Hoffmeister is a German surname. Notable people with the surname include:
Bert Hoffmeister (1907–1999), Canadian Army officer, businessman, and conservationistCuno Hoffmeister (1892–1968), German astronomer and geophysicist, founder of Sonneberg ObservatoryEdmund Hoffmeister (1893–1951), German, Army officer, GeneralleutnantFrank Hoffmeister (born 1965), German backstroke swimmerFranz Hoffmeister (1898–1943), Roman Catholic priestFranz Anton Hoffmeister (1754–1812), German composer and music publisherFreya Hoffmeister (born 1964), German expeditioner and sea-kayakerGunhild Hoffmeister (born 1944), East German-German female middle distance runnerJesse Hoffmeister (1872–1933), Major League Baseball player