EC number 6.1.1.21 ExPASy NiceZyme view | CAS number 9068-78-4 | |
Alt. names histidyl tRNA synthetase, Jo-1 | ||
In enzymology, a histidine-tRNA ligase (EC 6.1.1.21) is an enzyme that catalyzes the chemical reaction
ATP + L-histidine + tRNAHis
The 3 substrates of this enzyme are ATP, L-histidine, and tRNA(His), whereas its 3 products are AMP, diphosphate, and L-histidyl-tRNA(His).
This enzyme participates in histidine metabolism and aminoacyl-trna biosynthesis.
Nomenclature
This enzyme belongs to the family of ligases, to be specific those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-histidine:tRNAHis ligase (AMP-forming). Other names in common use include histidyl-tRNA synthetase, histidyl-transfer ribonucleate synthetase, and histidine translase.
References
Histidine—tRNA ligase Wikipedia(Text) CC BY-SA