Higouménakis' sign

Higouménakis' sign is a unilateral enlargement of the sternoclavicular portion of the clavicle, seen in congenital syphilis. It is an end result of neonatal periostitis.

This sign was first described by George Higoumenakis in 1927 in the Greek periodical Proceedings of the Medical Society of Athens (Πρακτικά Ιατρικής Εταιρείας Αθηνών). He subsequently published the description of the sign in a German article, making the sign more known among dermatologists. Thus, the sign was named after George Higoumenakis.