Hightower is a surname. Notable people with the surname include:
Caroline Warner Hightower (born 1935), American development consultant
Chelsie Hightower (born 1989), American ballroom dancer
Cullen Hightower (1923 - 2008), American author of quips and quotes
Dick Hightower (1930-2007), American football player
Dont'a Hightower (born 1990), American football player
George Robert Hightower (fl. early 20th century), American academic, President of the Mississippi Agricultural and Mechanical College
Jack English Hightower (born 1926), American politician from Texas; U.S. Representative
James Robert Hightower (1915-2006), American professor of Chinese at Harvard University
Jim Hightower (born 1943), American activist and commentator
Keith Hightower (born 1957), American politician; mayor of Shreveport, Louisiana
Loren Hightower (contemporary), American ballet and musical theater dancer
Rosella Hightower (born 1920), American ballerina
Rosetta Hightower, American singer
Scott Hightower (born 1952), American poet and teacher
Tim Hightower, (born 1986), American football player
Yolanda Hightower, American competitor in field hockey at the 1988 Summer Olympics
Fictional characters:
Moses Hightower (character), a character in the film and series Police Academy
Bob Hightower, played by John Wayne in the 1949 western film 3 Godfathers
Reverend Gail Hightower, a character in the novel Light in August (1932) by William Faulkner
Reno Hightower, played by Kurt Russell in The Best of Times (1986)
Harrison Hightower, fictional character of Tokyo DisneySea's Tower of Terror
Steve Hightower, played by Steve Harvey in his TV series The Steve Harvey Show
Wes Hightower, in the film Urban Cowboy (1980), portrayed by Scott Glenn
Sheriff Hightower, in the 1990 film Flashback
Madeleine Hightower, in the TV series "The Mentalist"