Highsmith is a surname. Notable people with the surname include:
Alonzo Highsmith (born 1965), American professional football playerCarol M. Highsmith (born 1946) American photographer, author, and publisherDon Highsmith (born 1948), American football playerJim Highsmith (born 1945), author of multiple books in the field of software development methodologyMargaret Highsmith Dickson, Democratic member of the North Carolina General AssemblyPatricia Highsmith (1921–1995), American novelist