Hetzel is a surname. Notable people with the surname include:
Amy Hetzel (born 1983), Australian water polo player
Basil Hetzel (born 1922), Australian medical researcher
Eric Hetzel (born 1963), American baseball player
Fred Hetzel (born 1942), American basketball player
George Hetzel (1826–1899), American painter
Pierre-Jules Hetzel (1814–1886), French editor and publisher