Hesse is a German surname. Notable people with the surname include:
Adolf Friedrich Hesse (1809–1863), German composer
Eva Hesse (sculptor) (1936–70), painter and sculptor
Eva Hesse (writer) (born 1925), writer and translator
Hermann Hesse (1877–1962), German-born poet, novelist, and painter, Nobel Prize in Literature 1946
Karen Hesse (born 1952), US writer
Konrad Hesse (1919–2005), German jurist
Mary Hesse (born 1924), US philosopher
Otto Hesse (1811–74), German mathematician, known for the Hessian matrix
Paul Hesse (1857–1938), German malacologist
Richard Hesse (1868–1944), German zoologist
Walther Hesse (1846–1911), German microbiologist
