Herndon is a surname. Notable people with the surname include:
Adrienne McNeil Herndon (born 1869), African American woman in Atlanta, GeorgiaAlonzo Herndon (1858–1927), African-American businessmanAngelo Herndon (1913–1997), African-American communist organizerCharles Herndon, American SculptorDavid Herndon (born 1985), American professional baseball playerDavid R. Herndon (born 1953), United States federal judgeDon Herndon (1936–2009), American professional football playerEllen Lewis Herndon (1837–1880), wife of the 21st President of the United States, Chester A. ArthurJames Herndon (media psychologist) (born 1952), American media psychologistJames Herndon (writer) (1926–1990), American writer and educatorJimmy Herndon (born 1973), American professional football playerJ. Marvin Herndon (born 1944), American scientist who founded the georeactor theoryJoe Herndon (born 1949), American R&B and soul singer for The Spaniels and The TemptationsJohn Hunter Herndon (1813-1878), American judge and planter in antebellum TexasJudith Herndon (1941–1980), American Senator of West VirginiaJunior Herndon (born 1978), American professional baseball playerKelly Herndon (born 1976), American professional football playerKenneth Herndon (born 1985), American professional baseball playerLarry Herndon (born 1953), American professional baseball playerPatrick Herndon (1802–1836), American soldier who fought at the AlamoRaymon W. Herndon (1918–1942), United States Marine Corps Navy Cross recipientSteve Herndon (born 1977), American professional football playerSusan Herndon, American singer-song writerThomas Herndon (born 1985)Thomas H. Herndon (1828–1883), U.S. Representative from AlabamaTy Herndon (born 1962), American country music singerWilliam Herndon (lawyer) (1818–1891), law partner and biographer of Abraham LincolnWilliam Lewis Herndon (1813–1857), United States Navy scientist, explorer, and heroWilliam S. Herndon (1835–1903), U.S. Representative from Texas