Heparin sulfate lyase

In enzymology, a heparin-sulfate lyase (EC 4.2.2.8) is an enzyme that catalyzes the chemical reaction

Elimination of sulfate; appears to act on linkages between N-acetyl-D-glucosamine and uronate. Product is an unsaturated sugar.

This enzyme belongs to the family of lyases, specifically those carbon-oxygen lyases acting on polysaccharides. The systematic name of this enzyme class is heparin-sulfate lyase. Other names in common use include heparin-sulfate eliminase, heparitin-sulfate lyase, heparitinase I, and heparitinase II.