Henao is a Spanish surname. Notable people with the surname include:
Alexandra Henao (born c. 1970), Venezuelan cinematographer and film director
Carolina Colorado Henao (born 1987), Colombian swimmer
Hárrison Henao (born 1987), Colombian footballer
Jorge Henão (born 1962), Venezuelan swimmer
Juan Carlos Henao (born 1971), Colombian footballer
Luis Felipe Henao Cardona (born 1979), Colombian politician
Mauricio Hénao (born 1987), Colombian-American actor
Sebastián Henao (born 1993), Colombian cyclist
Sergio Henao (born 1987), Colombian cyclist
Zulay Henao (born 1979), Colombian-American actress
