Heisler is a surname. Notable people with the surname include:
Charles L. Heisler, American steam locomotive designerConrad Heisler, character in The Angry Hills (film)Gregory Heisler (born 1954), American photographerJindřich Heisler, a Czech surrealist poet, friend of ToyenL. Heisler Ball (1861–1932), physician and Delaware SenatorMark Heisler, a sports writers and authorMarcy Heisler (born 1967), musical theater writer and performerMike Heisler, American comic book writerTodd Heisler (born 1972), American photojournalistRandy Heisler (born 1961), American Olympic discus throwerStuart Heisler (1896–1979), film and television director