Heise is a surname. Notable people with the surname include:
Bob Heise (born 1947), American Major League Baseball player
David R. Heise (born 1937), American sociologist
Geoff Heise, American actor
Heinz Heise, German publishing house (including Heise Online)
Peter Arnold Heise (1830–1879), Danish composer (Drot og marsk, "King and Marshal")
William Heise, American film director, 1896 The Kiss