Handley is a surname. Notable people with the surname include:
Brian Handley, soccer player
Benjamin Handley (1784–1858), English politician and member of parliament for Boston
Chris J Handley, actor
Chris S Handley, comic collector
Colin Handley, stunt performer
Craig Handley, film director
David Handley, activist
Elizabeth Handley-Seymour (c.1873-1948), English fashion designer
George Handley (politician) (1752–1793), Governor of Georgia
George Handley (footballer) (1886–1952), English professional footballer
George B. Handley, professor of humanities at Brigham Young University
Harold W. Handley, Indiana governor
Jody Handley, English footballer
Joe Handley, Premier of Northwest Territories, Canada
Paul M. Handley, American freelance journalist, author of The King Never Smiles (biography of Thai King Bhumibol)
Ray Handley, American football coach
Taylor Handley, actor
Tommy Handley, comedian
Vernon Handley, conductor
Wayne Handley, airshow performer
Wal Handley, motorcycle racer