Handford is a surname. Notable people with the surname include:
Alick Handford (1869–1935), English cricketerClive Handford (born 1937), Anglican bishopFrank Handford, English rugby union playerJames Handford (1890–1948), English cricketerMartin Handford (born 1956), English writer and illustratorPeter Handford (1919–2007), English audio engineerPhil Handford (born 1964), English footballerRichard Handford, British television producerSanders Handford (1858–1917), English-born American cricketer