Handel (bioinformatics software package)

Handel is a suite of programs for multiple sequence alignment. Since it is based on a model of DNA sequence evolution that explicitly incorporates insertion and deletion events, it effectively doubles as a program for ancestral sequence reconstruction.

The theory underpinning Handel is based on the finite state transducer, a concept borrowed from computational linguistics.

Handel can be downloaded as part of the DART software package. It accepts input files in Stockholm format.