Halphen is a surname. Notable people with the surname include:
Éric Halphen (born 1959), French judge
Eugène Halphen (1820-1912), French historian, poet and book editor.
Fernand Halphen (1872–1917), French composer
Georges Henri Halphen (1844–1889), French mathematician
Gustave Halphen (d. 1872), French diplomat.
Louis Halphen (1880–1950), French medieval-historian
Baroness Noémie de Rothschild (1888-1968), born Noémie Halphen, French philanthropist
