Halpern is a variation of the Jewish surname Heilprin and may refer to:
Baruch Halpern, Jewish studies
Charles Halpern, lawyer
Charna Halpern, co–founder of ImprovOlympic
Cheryl Halpern, chair of the Corporation for Public Broadcasting
David Halpern, (b. 1955), sprint canoer
Diane F. Halpern, American psychologist
Ida Halpern, (1910–1987), Austrian musicologist
Jack Halpern (chemist), (b. 1925), Polish chemist
Jack Halpern (linguist), lexicographer
Jake Halpern, (b. 1975), American writer
Jeff Halpern, (b. 1976), American ice hockey player
Joseph Halpern, computer science professor
Justin Halpern, (b. 1980), American writer, author of Shit My Dad Says and I Suck at Girls
Lily Halpern, American singer
Mitch Halpern, (1967–2000), boxing referee
Mortimer Halpern, (1909-2006), American Broadway stage manager
Moyshe Leyb Halpern, (1886–1932), American Yiddish poet
Paul Halpern, (b. 1961), American science writer and physicist
Ralph Halpern (born 1938), Austrian-born British businessman
Yisroel Halpern (aka Yisroel Karduner), (d. 1920), rabbi and Breslover Hasid