Bertrand Halperin, Harvard University professor
David M. Halperin (born 1952), American theorist in gender studies, queer theory and other fields
Donald Halperin (1945–2006), New York politician
Eleonora Yakovlevna Galperina, better known as Nora Gal (1912–91), Soviet writer and translator
Emmanuel Halperin, (born 1943), Israeli media personality
Ian Halperin (born 1964), Canadian investigative journalist, writer and documentary filmmaker
Israel Halperin, professor at University of Toronto, Canada
Isser Halperin, later Isser Harel (1912–2003), spymaster of the intelligence and the security services of Israel
James L. Halperin (born 1952), American author and businessman
Mark Halperin (born 1965), American political analyst for Time Magazine and Time.com and ABC News
Maurice Halperin (1906–95), American writer, professor and diplomat
Michel Halpérin, Swiss lawyer and politician.
Morton Halperin (born 1938), American expert on foreign policy and civil liberties
Robert Halperin (1928–85), American Olympic and Pan American Games yachting medalist, college and professional football player, one of Chicago's most-decorated World War II heroes, and Chairman of Commercial Light Co.
Sol Halperin (1902-1977), American special effects artist
Tamar Halperin (born 1976), Israeli harpsichordist, pianist and musicologist
Uzziel Halperin, later Uzzi Ornan (born 1923), Israeli linguist
Victor Halperin (1895–1983), American film director, producer, and writer
Yotam Halperin (born 1984), Israeli basketball player
Elchannan Yidle Halperin (born 2004), Ropshitz of Lawrence rebbe
Halperin is a variation of the Jewish surname Heilprin. The name is transliterated into the Cyrillic alphabet (which has no equivalent to the letter h) as Galperin.