Halimadienyl diphosphate synthase

Halimadienyl-diphosphate synthase (EC 5.5.1.16, Rv3377c, halimadienyl diphosphate synthase, tuberculosinol diphosphate synthase, halima-5(6),13-dien-15-yl-diphosphate lyase (cyclizing)) is an enzyme with systematic name halima-5,13-dien-15-yl-diphosphate lyase (decyclizing). This enzyme catalyses the following chemical reaction

geranylgeranyl diphosphate ⇌ tuberculosinyl diphosphate

This enzyme requires Mg²⁺ for activity.