Suvarna Garge (Editor)

HT 2157

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Covid-19
ATC code  none
PubChem CID  1471834
Formula  C21H13F3N2O
Molar mass  366.335 g/mol
CAS Number  303149-14-6
IUPHAR/BPS  6126
3D model (Jmol)  Interactive image
HT-2157 httpsuploadwikimediaorgwikipediacommonsthu

HT-2157 (former code name SNAP-37889) is a drug which acts as a selective non-peptide antagonist for the receptor GAL-3, which is usually activated by the neuropeptide galanin. Blocking this receptor with HT-2157 produced increased serotonin release, as well as producing antidepressant and anxiolytic effects in animal studies, and it was also being researched for treatment of cognitive dysfunction. All human clinical trials were terminated due to safety concerns however, and new GAL-3 antagonists are now being sought instead.

References

HT-2157 Wikipedia


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