Puneet Varma

HRK (gene)

Updated on
Share on FacebookTweet on TwitterShare on LinkedIn
Species  Human
Entrez  8739
Human  Mouse
Ensembl  ENSG00000135116
HRK (gene)
Aliases  HRK, DP5, HARAKIRI, harakiri, BCL2 interacting protein
External IDs  HomoloGene: 136405 GeneCards: HRK

Activator of apoptosis harakiri is a protein that in humans is encoded by the HRK gene.



Activator of apoptosis Hrk regulates apoptosis through interaction with death-repressor proteins Bcl-2 and Bcl-X(L). The HRK protein lacks significant homology to other BCL2 family members except for an 8-amino acid region that was similar to the BCL2 homology domain-3 (BH3) motif of BIK. HRK interacts with BCL2 and BCLXL via the BH3 domain, but not with the death-promoting BCL2-related proteins BAX, BAK, or BCLXS. HRK localizes to membranes of intracellular organelles in a pattern similar to that previously reported for BCL2 and BCLXL.


HRK (gene) has been shown to interact with:

  • BCL2-like 1, and
  • Bcl-2.
  • References

    HRK (gene) Wikipedia

    Similar Topics
    Shanghai Affairs
    Otto Pfister
    Elaine Donnelly (writer)