Puneet Varma

HRK (gene)

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Species  Human
Entrez  8739
Human  Mouse
Ensembl  ENSG00000135116
HRK (gene)
Aliases  HRK, DP5, HARAKIRI, harakiri, BCL2 interacting protein
External IDs  HomoloGene: 136405 GeneCards: HRK

Activator of apoptosis harakiri is a protein that in humans is encoded by the HRK gene.

Contents

Function

Activator of apoptosis Hrk regulates apoptosis through interaction with death-repressor proteins Bcl-2 and Bcl-X(L). The HRK protein lacks significant homology to other BCL2 family members except for an 8-amino acid region that was similar to the BCL2 homology domain-3 (BH3) motif of BIK. HRK interacts with BCL2 and BCLXL via the BH3 domain, but not with the death-promoting BCL2-related proteins BAX, BAK, or BCLXS. HRK localizes to membranes of intracellular organelles in a pattern similar to that previously reported for BCL2 and BCLXL.

Interactions

HRK (gene) has been shown to interact with:

  • BCL2-like 1, and
  • Bcl-2.
  • References

    HRK (gene) Wikipedia


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