Species Human Entrez 8739 | Human Mouse Ensembl ENSG00000135116 | |
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Aliases HRK, DP5, HARAKIRI, harakiri, BCL2 interacting protein External IDs HomoloGene: 136405 GeneCards: HRK | ||
Activator of apoptosis harakiri is a protein that in humans is encoded by the HRK gene.
Contents
Function
Activator of apoptosis Hrk regulates apoptosis through interaction with death-repressor proteins Bcl-2 and Bcl-X(L). The HRK protein lacks significant homology to other BCL2 family members except for an 8-amino acid region that was similar to the BCL2 homology domain-3 (BH3) motif of BIK. HRK interacts with BCL2 and BCLXL via the BH3 domain, but not with the death-promoting BCL2-related proteins BAX, BAK, or BCLXS. HRK localizes to membranes of intracellular organelles in a pattern similar to that previously reported for BCL2 and BCLXL.
Interactions
HRK (gene) has been shown to interact with:
References
HRK (gene) Wikipedia(Text) CC BY-SA