Species Human Entrez 3215 | Human Mouse Ensembl ENSG00000120075 | |
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Aliases HOXB5, HHO.C10, HOX2, HOX2A, HU-1, Hox2.1, homeobox B5 External IDs MGI: 96186 HomoloGene: 37585 GeneCards: HOXB5 | ||
Homeobox protein Hox-B5 is a protein that in humans is encoded by the HOXB5 gene.
Function
This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in lung and gut development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML) and the occurrence of bronchopulmonary sequestration (BPS) and congenital cystic adenomatoid malformation (CCAM) tissue.
References
HOXB5 Wikipedia(Text) CC BY-SA