Species Human Entrez 3214 | Human Mouse Ensembl ENSG00000182742 | |
Aliases HOXB4, HOX-2.6, HOX2, HOX2F, homeobox B4 External IDs MGI: 96185 HomoloGene: 32095 GeneCards: HOXB4 | ||
Homeobox protein Hox-B4 is a protein that in humans is encoded by the HOXB4 gene.
Function
This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Intracellular or ectopic expression of this protein expands hematopoietic stem and progenitor cells in vivo and in vitro, making it a potential candidate for therapeutic stem cell expansion.
References
HOXB4 Wikipedia(Text) CC BY-SA