Entrez 3214 | Ensembl ENSG00000182742 | |
External IDs MGI: 96185 HomoloGene: 32095 GeneCards: HOXB4 |
Function
This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Intracellular or ectopic expression of this protein expands hematopoietic stem and progenitor cells in vivo and in vitro, making it a potential candidate for therapeutic stem cell expansion.
References
HOXB4 Wikipedia(Text) CC BY-SA