Neha Patil

HOXA2

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Species  Human
Entrez  3199
Human  Mouse
Ensembl  ENSG00000105996
Aliases  HOXA2, HOX1K, MCOHI, homeobox A2
External IDs  MGI: 96174 HomoloGene: 4901 GeneCards: HOXA2

Homeobox protein Hox-A2 is a protein that in humans is encoded by the HOXA2 gene.

Function

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. The encoded protein may be involved in the placement of hindbrain segments in the proper location along the anterior-posterior axis during development. Two transcript variants encoding two different isoforms have been found for this gene, with only one of the isoforms containing the homeodomain region.

HOXA2 controls the embryonic development of the lower and middle part of the face and of the middle ear. Mutations in it are known to cause microtia, hearing impairment, and cleft palate.

References

HOXA2 Wikipedia


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