Entrez 3207 | Ensembl ENSG00000005073 | |
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Aliases HOXA11, HOX1, HOX1I, RUSAT1, homeobox A11 External IDs MGI: 96172 HomoloGene: 4033 GeneCards: HOXA11 |
Function
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is involved in the regulation of uterine development and is required for female fertility. Mutations in this gene can cause radioulnar synostosis with amegakaryocytic thrombocytopenia.
References
HOXA11 Wikipedia(Text) CC BY-SA