| HORMAD1, CT46, NOHMA, HORMA domain containing 1|
MGI: 1915231 HomoloGene: 69415 GeneCards: HORMAD1
HORMA domain-containing protein 1 (HORMAD1) also known as cancer/testis antigen 46 (CT46) is a protein that in humans is encoded by the HORMAD1 gene.
HORMAD1 plays a key role in meiotic progression. Regulates 3 different functions during meiosis. It:
- ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single-stranded DSB ends.
- promotes synaptonemal-complex formation independently of its role in homology search.
- plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes (By similarity)