Trisha Shetty

HORMAD1

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Species  Human
Entrez  84072
Human  Mouse
Ensembl  ENSG00000143452
Aliases  HORMAD1, CT46, NOHMA, HORMA domain containing 1
External IDs  MGI: 1915231 HomoloGene: 69415 GeneCards: HORMAD1

HORMA domain-containing protein 1 (HORMAD1) also known as cancer/testis antigen 46 (CT46) is a protein that in humans is encoded by the HORMAD1 gene.

Function

HORMAD1 plays a key role in meiotic progression. Regulates 3 different functions during meiosis. It:

  1. ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single-stranded DSB ends.
  2. promotes synaptonemal-complex formation independently of its role in homology search.
  3. plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes (By similarity)

References

HORMAD1 Wikipedia


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