HORMAD1

Function

HORMAD1 plays a key role in meiotic progression. Regulates 3 different functions during meiosis. It:

1. ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single-stranded DSB ends.
2. promotes synaptonemal-complex formation independently of its role in homology search.
3. plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes (By similarity)