Species Human Entrez 8364 | Human Mouse Ensembl ENSG00000197061 | |
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Aliases HIST1H4C, H4/g, H4FG, dJ221C16.1, histone cluster 1, H4c External IDs MGI: 2140113 HomoloGene: 134234 GeneCards: HIST1H4C | ||
Histone H4 is a protein that in humans is encoded by the HIST1H4C gene.
Function
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.