Species Human Entrez 10870 | Human Mouse Ensembl ENSG00000126264 | |
Aliases HCST, DAP10, KAP10, PIK3AP, hematopoietic cell signal transducer External IDs MGI: 1344360 HomoloGene: 8024 GeneCards: HCST |
Hematopoietic cell signal transducer is a protein that in humans is encoded by the HCST gene.
This gene encodes a transmembrane signaling adaptor that contains a YxxM motif in its cytoplasmic domain. The encoded protein may form part of the immune recognition receptor complex with the C-type lectin-like receptor NKG2D. As part of this receptor complex, this protein may activate phosphatidylinositol 3-kinase dependent signaling pathways through its intracytoplasmic YxxM motif. This receptor complex may have a role in cell survival and proliferation by activation of NK and T cell responses. Alternative splicing results in two transcript variants encoding different isoforms.
References
HCST (gene) Wikipedia(Text) CC BY-SA